Senescent cells and cancer cells as apoptosis suppressors: Causes and effects

The death of some senescent cells (KS), as well neoplastic (KN), can be paradoxically inhibited at the stage apoptosis. Thus, KS become inhibitors oncogenesis beginning phenomenon. influence and KN on inhibition apoptosis is multidirectional, which presented graphically in form Euler’s mathematical circles (Fig. 2). Senescence, like apoptosis, may to extent inhibit oncogenesis. process also associated with non-apoptotic death, i.e. entosis, autophagy, autophagocytosis participation lysosomes. autophagy involve cell proteolytic system via ubiquitin-proteasome (UPS), polyubiquitination suppressor proteins, e.g. p53 protein, leads Therefore, both above-mentioned processes favour paper presents role human endogenous retroviruses (HERs) oncogenesis, particular emphasis syncytin gene its induction placental cancer (choriocarcinoma, chorioepithelioma).